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WBC (Plasma cell disorder (Multiple myeloma older (lytic 'punched…

- - - - naive B (CD5, 20, 23, 19)
        
        elderly M>F
        
        AIHA (IgG>IgM), hypogammaglobulinemia
        
        richter transformation (to DLBCL)
        - smudge cell
    - - TRAP
        
        red pulp splenomegaly, "dry tap"
        
        2-CDA ADenosine deaminase inhibit
        
        mature B cell CD 20, 25, 103
    - - CD4+ T
        
        HTLV-1
        
        lytic bone
        
        Japan/carribbean: RASH, LAD
    - - CD4+ T
        
        pautrier micro abscess
        
        sezary cerebriform nuclei
    - - may become ALL (CD34)
        
        leukocytosis (~!00k wBC) + basophil (which is so rare), eosinophil
        
        dec LAP (high = leukemoid rxn;infection)
        
        older, splenomegaly
  - - - APML (promyelolytic)
        
        t(15:17)
        
        Auer rod (MPO aggregates) -> DIC
        
        elderly common
        
        ATRA (binds to RAR, lets blasts mature
        
        t(9:22) bad px
        
        no CD, less -megaly (vs. ALL)
        
        No MPO
        
        Megakaryocytic (< 5yr Down)
        
        monocytic (infiltrate gum)
    - - B-cell ALL
        
        children common, bone pain, -enia, anemia
        
        t(12;21); (>5yr Down)
        
        CALLA (CD 10+), CD 19, 20
        
        chemo responsive (scrotum and CSF need prophylaxis)
        
        if in adult (less common) can be a crisis phase of CML, t(9:22), bad px
      - T-cell ALL
        
        CD7+ (no CD10)
        
        teen-20s
        
        mass (lymphoid, mediastinum [pleural effusion], tumor (SV syndrome)
- - - - small B+ (CD20)
        
        t (14:18): BcL2 Ag (immortalize)
        
        Rituximab (anti CD20)
        
        CALLA
    - - t(11:14)
        
        Cyclin D1
        
        CD23 - (similar to CLL CD19/20/5)
        
        aggressive, painless LAD ina dult
    - - MALTnoma
        
        post germinal B
    - - CALLA
- - - - NADPH oxidase deficiency (dec oxidative burst)
        NBT neg
        cat+ vulnerable
    - - albinism
        giant granles in leukocytes/paltelt (from golgi)
        neutropenia, trafficking, phagolysosome malfx
    - - do well w/ infection except candida w/ diabetic (mostly asymptomatic)
        NBT +
    - - inc circ neutrophil
        delayed separation of umb cord
        recurrent bacterial infection, no pus (neut can't adhere)