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H5 CT (TYPICAL CT: (Cells do NOT contact each other (no tightly packed…

- - - - Inflammation (response to injury)
        
        Fluid may accumulate
        
        Ulceration = loss of overlying epithelum
      - Infection (help lymphatic organs)
      - Neoplasia (CT tumors: sarcoma & lymphoma)
    - - Resident Cells
        (stable populations)
        
        Fibroblasts
        
        secrete fibers & ground substance ECM
        
        Fibrocytes = inactive
        Myofibroblasts = wound healing, help w/ closure
        
        Unilocular adipocytes
        synthesize & store lipids in a single lipid inclusion
        
        Multiocular adiopcytes
        thermogenesis - store lipids
        
        Macrophages
        
        Phagocytize debris
        
        APC
        
        Mediate inflammation
        
        Foreign Body Giant Cells
        (multiple macrophages, multinucleated)
        
        Bacteria
        
        Fungi
        
        Parasites
        
        Granulomas
        CC: TB
        
        Mast Cells
        
        Initiate & mediate inflammation
        
        CC: Urticaria, Anaphylaxis
        
        Plasma Cells (pale spot near nucleus = negative golgi)
        
        Secrete Abs
        
        Short lived vs. Long lived
        
        CC: Vaccines
      - Transient Cells
        (migrate into CT for immune resp)
  - - - Elastic Fibers (Orcein Stain)
        
        allow CT to stretch & relax w/ changes in tension
        
        Lungs
        Heart valves
        Dermis
        
        CC: Marfan Syndrome
      - Collagen
        
        Types I, II, III = Fibrullar
        
        Type I
        
        Type II
        
        Type III
        
        Type IV
        
        Reticular Fibers
        
        Glycosylated Type III
        
        Web-like meshwork
    - - PGs containing GAGs
        attract H2) - gel-like
      - Multiadhesive glycoproteins (MGPs)
        anchor ECM to each other and surrounding cells