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GENTAMICIN (PHARMACOKINETICS (DISTRIBUTION (do not penetrate well into…
GENTAMICIN
PHARMACOKINETICS
DISTRIBUTION
do not penetrate well into most cells, the CNS, or the eye.volume of distribution of these drugs is 25% of lean body weight and approximates the volume of extracellular fluid.
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ABSORPTION
Usually poorly absorbed in the GI tract however rapid absorption during a GI disease(E.g:Inflammatory Bowel Disease or Ulcers)
ELIMINATION
excreted almost entirely by glomerular filtration, achieving urine
concentrations of 50–200 μg/mL
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SIDE NOTES
Gentamicin, tobramycin, amikacin, and netilmicin can be used interchangeably for the treatment of most of the infections
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