Genetic Interactions
Multi-omics
modifier gene
Gene Regulatory Network
gene interaction network
protein interaction
genetic
https://string-db.org/
(2000) a database of known and predicted protein-protein interactions. The interactions include direct (physical) and indirect (functional) associations
regulatory interactions between TF and targets
https://omictools.com/clr-tool
(2007) Infers regulatory interactions between transcription factors and their targets using a compendium of gene expression profiles.
http://regulondb.ccg.unam.mx/
(2015/17)E.coli transcriptional regulatory network
Epistasis
multifactor dimensionality reduction (MDR)
https://sourceforge.net/projects/mdr/
gene-gene interaction
BOOST: A Fast Approach to Detecting Gene-Gene Interactions in Genome-wide Case-Control Studies
Author links open overlay
https://doi.org/10.1016/j.ajhg.2010.07.021
Detecting gene-gene interactions using support vector machines with L1 penalty
https://doi-org.ezproxy.lib.ucalgary.ca/10.1109/BIBMW.2010.5703819
Detecting gene–gene interactions that underlie human diseases
Nature Reviews Genetics volume 10, pages 392–404 (2009)
Yeast Cell network
http://thecellmap.org/
combined
https://genemania.org/
(2010) finds other genes that are related to a set of input genes, using a very large set of functional association data. Association data include protein and genetic interactions, pathways, co-expression, co-localization and protein domain similarity
http://www.geneticinteractions.org/research.html
To faciliate experimentation and integrated computational analysis with model organism PPI networks, we have integrated known, experimental and predicted PPIs for five model organisms and human in the I2D database.
Experiment Design
Data identification
Feature identification
Develop training strategy
Testing and validation strategy
Identify possible pitfalls
From where? Additional data? Available features?
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Algorithm to use based on features
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Test cases? Benchmark?