Genetic Interactions

Multi-omics

modifier gene

Gene Regulatory Network

gene interaction network

protein interaction

genetic

https://string-db.org/
(2000) a database of known and predicted protein-protein interactions. The interactions include direct (physical) and indirect (functional) associations

regulatory interactions between TF and targets

https://omictools.com/clr-tool
(2007) Infers regulatory interactions between transcription factors and their targets using a compendium of gene expression profiles.

http://regulondb.ccg.unam.mx/
(2015/17)E.coli transcriptional regulatory network

Epistasis

multifactor dimensionality reduction (MDR)
https://sourceforge.net/projects/mdr/

gene-gene interaction

BOOST: A Fast Approach to Detecting Gene-Gene Interactions in Genome-wide Case-Control Studies
Author links open overlay
https://doi.org/10.1016/j.ajhg.2010.07.021

Detecting gene-gene interactions using support vector machines with L1 penalty
https://doi-org.ezproxy.lib.ucalgary.ca/10.1109/BIBMW.2010.5703819

Detecting gene–gene interactions that underlie human diseases
Nature Reviews Genetics volume 10, pages 392–404 (2009)

Yeast Cell network
http://thecellmap.org/

combined

https://genemania.org/
(2010) finds other genes that are related to a set of input genes, using a very large set of functional association data. Association data include protein and genetic interactions, pathways, co-expression, co-localization and protein domain similarity

http://www.geneticinteractions.org/research.html
To faciliate experimentation and integrated computational analysis with model organism PPI networks, we have integrated known, experimental and predicted PPIs for five model organisms and human in the I2D database.

Experiment Design

Data identification

Feature identification

Develop training strategy

Testing and validation strategy

Identify possible pitfalls

From where? Additional data? Available features?

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Algorithm to use based on features

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Test cases? Benchmark?