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modelling drug delivery to GBM (intracerebral bolus/infusion (transport…
modelling drug delivery to GBM
intracerebral bolus/infusion
transport within interstitium
healthy tissue
convection
diffusion
porous matrix stiffness
tumor tissue
modified convection
modified diffusion
higher cellular matrix stiffness
heterogeneity
entry to tumour
difference in porous matrix stiffness
high IF pressure in tumor
drug elimination
interstitial fluid
adsorption
proteins
lipids
cells
degradation
hydrolysis
interstitial fluid - tumour
adsorption
degradation
hydrolysis
entry to tumour cell
tumour membrane permeability
transport
phagocytosis
adsorption
cytosol
adsorption
degradation
hydrolysis
de-novo synthesis of proteasomes
intravenous
blood brain barrier
tight junction transport barriers
passive diffusion barriers
damage of endothelial cells
carrier/receptor barriers
blood brain tumor barrier
modified/damaged endothelium
heterogeneous permeability
carrier mediated barriers
tight junction transport barriers
adsorption by membranes
passive diffusion barriers
drug elimination in blood
adsorption
proteins
lipids
cells
hydrolysis
uptake by blood cells
enhancement strategies
physio-chemical drug properties