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NAFLD (Tests (Increased aminotransferase level, AST/ALT ratio < 1,…
NAFLD
Tests
Increased aminotransferase level
AST/ALT ratio < 1
Possible increase in alkaline phosphatase
Increase gamma–glutamyl transpeptidase (GGT)
High serum cholesterol
Altered gut microbiota
Increased production of fatty acids in bowel
small bowel permeability
Pro-inflammatory cytokines
Dietary
High fructose
High caloric
High fat
Insulin resistance
Impaired inhibition of adipose tissue lipolysis
Increased production of inflammatory cytokines
Mitochondrial dysfunction
Oxidative stress and ROS (reactive oxygen species)
Endoplasmic reticulum stress
Environmental factors
Sedentary lifestyle
Dyslipidemia
Type 2 diabetes
Obesity
Liver biopsy with macrovescular fatty infiltration.
Metabolic syndrome
Absence of alcohol consumption
Absence of Hep B & C
Genetic susceptibility