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Infectious Canine Hepatitis (Clinical signs (Fever, Hepatomegaly,…
Infectious Canine Hepatitis
Characteristics
Icosahedral, non-enveloped virus
Linear ds DNA virus
Penton fibres project from vertices
Each fibre has a terminal knob
Knobs agglutinate some mammalian RBCs
Resistant in the Environment
replicates in nucleus
Replication
Binding
Internalisation
Endocytosis
Uncoating of genome
Viral DNA replication
proteins production
Viral assembly
Cell lysis
Transmission
Virus excreted in urine of recovered dogs for a duration of 6 - 9 months
Salvia
faeces
Treatment/Prevention
hardy in environment however Steam cleaning and powerful disinfectants will kill it
Fluid therapy
Manage hepatic encephalopathy
Modified Live vaccine
CAV - 2 vaccines (long lasting)
pathogenesis
Cytopathic effects due to viral replication
Virus shed in urine
Acute Hepatitis
vascular endothelial haemorrhage
Antibody production -> Immune Complex Formation
Ocular disease
Glomerulinephritis
Clinical signs
Fever
Hepatomegaly
Tonsillar/lymph node enlargement
haemorrhage +/- abdominal effusion
Corneal opacity
Signs last 5 -7 days if dog survives
Diagnosis
Clinical signs/History
Developing corneal opacity (late in disease process)
Bloods
Early leukopenia
Variable raised liver enzymes, hyperbilirubinaemia
Specific tests
IFA
Virus isolation
HI
Infectious Canine Hepatitis (CAV - 1)