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hypersensitivity (Type2 (antibody-mediated cellular dysfunction…
hypersensitivity
Type2
complement and Fc recpetor-mediated inflammation
Goodpasture
antibody-mediated cellular dysfunction
Myasthenia gravis
Graves disease
opsonization and phagocytosis
Erythroblastosis fetalis
Type4
Cd4
Th1
Granulomatous inflammation肉芽腫性炎
接觸性皮膚炎
Tuberculin test
Th17
Cd8
Type1糖尿病
疾病統整
RA風濕性關節炎
Multiple sclerosis
第一型糖尿病
inflammatory bowel
Psoriasis銀屑病
Contact sensitivity
Type3
systemic
急性serum sickness
不確定（鏈球菌感染後的腎絲球腎炎）Poststreptococcus glomerulonephritis
慢性serum sickness
SLE
local
Arthus reaction
Type 1
Autoimmune disease
Lupus erythematosus紅斑性狼瘡
檢驗dsDNA、smith antibody
Type3過敏反應（若血球有破壞則是第二型）
常見症狀Man Bird Soap
三大常見影響
血液
關節炎
皮膚
腎臟病變
Diffuse lupus nephritis：full house
皮膚病變
Lupus band test
心臟病變
Libman-Sacks endocarditis
肺部病變
antiphospholipid antibody syndrome
cardiolipin
beta2-glycoprotein
慢性圓形紅斑性狼瘡Chronic discoid lupus erythematosus
SCLE：subcutaneous cutaneous lupus erythematosus
Sjogren syndrome
症狀
Xerostomia(口乾症)
鼻粘膜乾燥、復發性支氣管炎、肺炎
Keratoconjunctivitis sicca(乾燥性角膜結膜炎)
Extraglandular manifestations(腺體外病徵)
anti-SSA, antiSSB
Primary無伴隨其他疾病，Secondary有其他自體免疫，例如RA
淚腺唾腺
系統性硬皮症Systemic sclerosis
分類
diffuse
anti-Scl 70
limited
機轉：血管變窄組織缺氧，誘導纖維化、鈣化，指尖萎縮變黑
症狀
食道
Barrett's esophagus
腎臟病變
IgG4-related disease
CREST syndrome