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Chronic Asthma : (Epidemiology (Affects approximately 300 million people…
Chronic Asthma :
Epidemiology
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Responsible for about 250,000 deaths per year
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Pathophysiology
bronchospasm, edema, mucus secretion with airflow obstruction
Cell activation of allergen-specific IgE stimulates the acute phase asthmatic reaction and mast cells bind to the surface
IgE binding occurs, antigen mast cells release bronchoconstrictor mediators together with histamine prostaglandins, platelet activating factor and interleukins.