Chronic Asthma :
Pathophysiology
Epidemiology
Treatment
Clinical Presentation
Diagnosis
bronchospasm, edema, mucus secretion with airflow obstruction
Cell activation of allergen-specific IgE stimulates the acute phase asthmatic reaction and mast cells bind to the surface
IgE binding occurs, antigen mast cells release bronchoconstrictor mediators together with histamine prostaglandins, platelet activating factor and interleukins.
Affects approximately 300 million people and children are affected more than adults
Responsible for about 250,000 deaths per year
Genetics
Gender
Environmental allergens
Obesity
Chest constriction
Psychological factors
Wheezing
Dyspnea
Coughing
Prolonged expirations
Antibiotics
Short-acting beta-agonist
Anti-inflammatory medications
Smoking cessations
Steroids
Medical history
Lung function test
Family history
Allergy testing
Recurrent episodes of wheezing