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CERVICAL CARCINOMA (Adenocarcinoma (40-80% linked to HPV, Linked to use of…

- - - - If it persists will integrate into host DNA & make viral oncogenes
      - once integrated, makes viral genes:
        E6=p53
        E7=pRB
    - - Latent
        
        remains in nucleus/integrated in host genome
      - Productive
        
        viral DNA replicates & produces koilocytes
- - - - Haemorrhage
      - Infection
      - Hydronephrosis
- - - - Nodular lesions kwiEctocervix
      - Ulcerating lesions kwiEctocervix
    - - Atypical squamous cells with/without keratin infiltrating cervical stroma
  - - - Cervical Intraepithelial Neoplasia(CIN1/2/3)
      - CIN1
        
        46% persists over 2 years
        
        15% progress to HSIL
        
        44% resolves
      - CIN 3
        
        33% progress to malignancy(invasive)
    - - Low Grade Squamous intraepitthelial Lesion(LSIL)
        
        Goes hand in hand with CIN1
        
        HPV infection of cervix (condyloma acuminata)
      - High Grade Squamous Intraepithelial Lesion(HSIL)
        
        Goes hand in hand with CIN 2 & 3
        
        With CIN 3, it is carcinoma in situ ( meaning hasn't breached BM)