Please enable JavaScript.
Coggle requires JavaScript to display documents.
KATIE Viral Gastroenteritis L33 (VIRULENCE FACTORS (NSP4 Enterotoxin …
KATIE
Viral Gastroenteritis
L33
VIRULENCE FACTORS
NSP4 Enterotoxin
:star2:only virus that encodes a enterotoxin
Winter Vomiting Disease
5-7 day course
Kids <2 yo
ROTAVIRUS :wheel_of_dharma:
CAUSES:
-Stimulates secretion w/o histological alterations
-Triggures Ca-dep. signal transduction in intoxicated cell
-Mobilized Ca from ER
-Chloride secretion enhanced
TWO RECEPTOR MODEL:
**
Only a few infected host cells killed b/c one infected cell can make a lot of NSP4 that can stimulate many other neighboring cells*
Viron binds cell surface receptor
NSP4 produced in infected cell -> released into intestinal lumen
NSP4 is bound at separate specific receptors on adjacent cells.
Secretory pathways stimulated
Acid Resistant Capsid
NO Seasonality
5-12 day course
(serotypes 40 & 41)
ENTERIC ADENOVIRUS
LOW Dose pathogen
Resistant to inactivation
Re-Infection Likely
:handshake:
P2P Transmission very easy!
Older children
Adults
CALICIVIRUSES
Noroviruses
Sapporo-like viruses