Please enable JavaScript.
Coggle requires JavaScript to display documents.
Cell-associated Pattern Recognition Receptors (PRRs) (NOD-like receptors…
Cell-associated Pattern Recognition Receptors (PRRs)
Toll-like receptors (TLRs)
C-type lectin receptors
Calcium dependent transmembrane proteins
Found of Macrophages
Scavenger Receptors
React with lipid-bound macromolecules such as LPS or lipopeptides
Found of Macrophages
NOD-like receptors (NLRs)
Soluble in cytoplasm
NOD1
NOD2
Recognize peptidoglycan degradation products
Structure
N-terminal caspase-recruitment domain (CARD)
Central oligomerization
C-terminal leucine-rich repeats that sense PAMPs
Activation
C-term inhibits N-term
When, PAMP binds, C-Term dimerizes and activates N-Term
N-term starts kinase cascade to activate NFkB
Interleukin-1 receptors
Bind to interleukin-1 cytokines
Found in several tissues
Activation initiates kinase cascade
2 more items...
