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Tumors / Neoplasia -Unregulated -Irreversible -Monoclonal (GROWTH…
Tumors / Neoplasia
-Unregulated
-Irreversible
-Monoclonal
Benign
Epithelial
From Glands
ADENOMA
From Cystic Masses w/ Neoplastic Columnar or Cuboidal "Gland Cells"
CYSTADENOMA
From Exophytic Growth of Epithelial Cells
PAPILLOMA
Malignant
Epithelial
From Squamous-Lined Structures
SQUAMOUS CARCINOMA
From Gland Forming / Columnar Epithelia
ADENOCARCINOMA
From Transitional Epithelium
(bladder, ureters, renal pelvis)
TRANSITIONAL CARCINOMA
From Renal Collecting Tubules
RENAL CARCINOMA
Site-Specific
EX: HEPATOCELLULAR CARCINOMA
Hemapoietic Neoplasm
can never be benign
Formed of Masses of Lymphocytes
LYMPHOMA
Formed from Bone Forming Cells
Diffuse
LEUKEMIA
METASTASIS:
3 Pathways of Spread
1. Lymphatic
2. Hematogenous
(sarcomas)
3. Seeding of Body Cavities & Surfaces
Peritoneal
Ovarian Cancer
Gastric & Intestinal Carcinoma
Pancreatic Carcinoma
Pleural
Pericardial cavities
Other:
-CNS
-Urinary Tract Seeding
Rare Metastasizers (2)
BCC of Skin
Glioma of Brain
2 COMPONENTS
1. Parenchyma (neoplastic cells)
2. Stroma (blood vessels & connective tissue)
Critical for growth & spread
"Tumor DESMOPLASIA"
:arrow_double_down:Desmoplasia
Sarcomas & Carcinomas
Soft to touch
:arrow_double_up:Desmoplasia
Most Carcinomas
(ex: scirrhous)
Hard to touch
GROWTH PATTERNS
Exophytic Growth
Sessile
(broad base)
Pedunculated Polyp
(narrow base/pedicle)
Papillary
(finger-like projections)
Endophytic Growth
Benign
Diffuse-Infiltrating Cancer
MISCELLANEOUS LESIONS
2 or more cell types in tumor
MIXED TUMOR
From all 3 Germ Layers
TERATOMA
From a Disorganized, Benign Mass of Cells
(indigenous to site)
HAMARTOMA
From Normal Tissue in Abnormal Location
CHORISTOMA
(Heterotopia; Ectopia)
Treatment
Primary Form:
SURGERY
NEOADJUVANT Therapy
(before surgery)
ADJUVANT Therapy
(Post-surgery)