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Immunology (cells involved in immune response (T-lymphocytes (T-cells)…
Immunology
cells involved in immune response
B-lymphocytes (B cells)
humoral response comes from stem cells
travel to side of injury
plasma cells
recognize antigen and bind
antigenic determinate - antigen and antibody bind once they bind antigen is no longer active
memory cells hold memory and multiply
proliferates in presence of antigen
recognize previously encountered antigens
humoral immune response^^
produce antibodies (immunoglobulins)
T-lymphocytes (T-cells)
cell mediated immunity
attacks invaders and runs the show
t-receptor:differentiate them
t-helpers: increase B-cells, stimulate production of t-memory and t-suppressors
t-memory:cells recognize previously encountered cells
t-suppressors: tun off function of B-cells
t-killers: (cytotoxic) active against viruses and tumors have NO memory
macrophages
phagocytosis
link between inflammation and immune response
antigen presenting: enhances immune response
produce monotones
cytokines
produced by immune system
communication between cells
natural killer cells
large lymphocytes
strongest against viruses and cancers
dendritic cells
leukocyte
present on surface to another cell in immune system
antigen presenting cell
hypersensitivity to drugs
1 - anaphylaxis: urticaria, hives, angiodema (no itching, deeper)
2 - hemolytic : anemia - in blood, <iron
3 - serum sickness: penicillin, fever, swelling, renal issues, heart inflammation
4 - Delayed Rx cell mediated response to topical meds (mucositis)
autoimmune disease
depletion of immune system breaks down own tissue as antigens (rheumatoid arthritis)
immunodificiency
deficiency in #, function, inter-relationships of WBC and their products (AIDS)
hypersensitivity (allergic Rx)
Type 1
immediate
bee sting
IgE stimulation-->mast cells-->histamine-->edema
Type 2
Rh factor
antibody combines with antigen destroy tissue
hemolytic anemia: RBC destroyed, excess WBC
Type 3
auto immune
body fighting itself
tissue destruction
serum sickness
fixed drug reaction
Type 4
cell mediated
delated reaction (TB)
rejection of organ transplant/grafts
Acquired Immune Respone
cell memory
humoral immunity
T cells are primary
regulates cell mediated and humoral response
stem cells develop into T cells
cell-mediated immunity
antibody mediated
B cells are primary
stem cells-->B cells-->plasma cells or antibodies
Antigens
foreign substance triggers immune response
fungi-bacteria-viruses
autoimmune disease
passive
can occur naturally through exposure to antigen
active
passing antibodies from 1 person to another
REMINDER: B cells come from T cells and T cells produce plasma and memory cells