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Mononeuropathy (Nerves (Lower limb (Common peroneal (L4-S1) (Aetiology …
Mononeuropathy
Nerves
Upper limb
Ulnar
(C7-T1)
Clinical presentation
Sensory symptoms (little finger, lateral ring finger, medial hand)
Later, LMN weakness (small muscles), hypothenar wasting
Late claw hand of little/ring (hyperextension MCP, flexion ICP)
Diagnosis
History
Occupation: painters,
bricklayers, secretaries, etc.
Examination
Froment's +ve
Investigations
NCS (delayed)
Aetiology
Trauma (fracture, dislocation
at epicondylar groove of elbow)
Iatrogenic (after GA)
Degenerative (OA)
Management
Conservative
Avoid aggrevators
Surgical
Ulnar nerve decompression
Nerve transposition
Radial
(C5-T1)
Clinical presentation
Wrist drop (weak dorsiflexion and finger ext at MCPs)
Sensory loss (over dorsal 1st interossei)
Diagnosis
History
Trauma, alcohol
Examination
Weak dorsiflexion and finger ext MCPs
Sensory loss over dorsal 1st interossei
Investigations
NCS
Aetiology
Trauma (saturday night palsy, fractured
humerus shaft, axilla crutch trauma)
Iatrogenic (post-anaesthetic)
Management
Conservative
Physiotherapy
Splints
Median
(C6-T1)
Aetiology
Trauma
Autoimmune (RA, sarcoid, amyloid)
Idiopathic (most common)
Neoplastic (myeloma, lipomas)
Drugs (OCP)
Degenerative (OA)
Enfocrine (DM, acromegaly,
hypothyroid, pregnancy)
Clinical presentation
Sensory loss lateral 3 fingers,
worse at night, relieved by shaking hands
Later, LMN weakness (LOAF) and wasting of thenars
Epidemiology
Commoner in women
(smaller crossectional area
in carpal tunnel)
Diagnosis
History
Examination
Tinel's test +ve
Phelan's test +ve
Investigations
Bloods (FBC, CRP/ESR, glucose, U+E,
LFT, TFT, autoimmune - RF, ANA etc.)
NCS (slowing of signal)
Management
Conservative
Splinting
Medical
Diuretics
Local steroid injection
Surgical
Carpal tunnel release
Lower limb
Sciatic
(L4-S3)
Aetiology
Trauma (pelvic/femur fractures)
Neoplastic (pelvic tumour)
Clinical presentation
LMN weakness (hamstrings, lower leg, foot drop)
Sensory loss (lateral below knee)
Common
peroneal
(L4-S1)
Aetiology
Trauma (fibula head, sit crosslegged, cauda equina)
Peripheral neuropathy (DM etc.)
Degenerative (MND)
Clinical presentation
LMN weakness (
foot drop
, weak ankle dorsiflexion/eversion)
Sensory loss (dorsum of foot)
Preserved ankle reflexes
High steppage gait
Diagnosis
NCS
Management
Physio, OT, splints
Surgical intervention
Tibial
(L4-S3)
Aetiology
Trauma
Clinical presentation
LMN waekness (plantarflexion, invert foot, flex toes)
Sensory loss (dorsum of foot)
Lateral
cutaneous
(L2-L3)
Aetiology
Trauma (inguinal ligament)
Clinical presentation
Sensory change (pain/loss i
n anterolateral thigh)
Trunk
Phrenic
(C3-5)
Clinical presentation
Dyspnoea, orthopnoea
Diagnosis
History
Examination
Investigations
CXR (raised hemidiaphragm)
Aetiology
Infection (C3-5 hepes zoster, HIV, Lyme, TB)
Trauma (C-spine trauma)
Autoimmune (MS)
Iatrogenic (post-surgery)
Neoplastic (lung ca, thymoma, myeloma, paraneoplastic)
Degenerative (cervical spondylosis, muscular dystrophy)
Definition
Mononeuropathy
Lesion of individual peripheral
or cranial nerves
Mononeuritis multiplex
Lesion of 2+ peripheral nerves
(asymmetric distribution)
Aetiology
Mononeuritis
multiplex
Infection
HIV/AIDS
Leprosy
Autoimmune
Vasculitis (PAN, GPA)
RA
Sarcoidosis
Amyloidosis
Metabolic
DM
Neoplastic
Paraneoplastic syndrome
Mononeuropathy
Other
(specific to particular nerve)
Trauma