The speed of scientific breakthroughs and technological applications to improve the human condition is being accelerated by computational science and engineering, artificial intelligence, common database protocols, Moore’s law, and Nielsen’s law of Internet bandwidth (50% speed increase per year). Future synergies among synthetic biology, 3D/4D printing, artificial intelligence, robotics, atomically precise fabrication and other forms of nanotechnology, tele-everything, drones, augmented and virtual reality, falling costs of renewable energy systems, and collective intelligence systems will make the last 25 years of S&T change seem slow compared to the next 25.