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MM4 - Cell Division (i) (Cell Cycle Phases (G0 (optional (usually in…

- - - - replication of centrosomes (2 centrioles, microtubule organising centre) + organelles
  - - - usually in differentiated, older cells
- - - - chromosomes visible, consist of 2 sister chromatids joined @ centromere
      - early mitotic spindle forms
        
        centrosome becomes an aster when spindle emerges
    - - fragmented nuclear envelope
      - Kinetochore (protein @ centromere) forms
        
        attaches to specific DNA sequence on centromere
        
        essential for chromatid segregation
        
        without it: misdistribution of chromosomes
      - centrosomes @ poles
    - - chromosomes line up along metaphase plate
      - microtubules on spindle attach to microtubules on kinetochore
    - - sister chromatids pulled apart + dragged towards poles
    - - cytokinesis (cleavage forms)
      - nucelar envelope + nucleolus reform