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Liver cancers (Clinical presentation (Fever, Weight loss, RUQ pain,…

- - - - Epidemiology
        Most common type of
        primary liver cancer
        M>F
      - Aetiology
        Infection: HBV*, HCV
        Autoimmune: AIH, PSC
        Genetic: haemachromatosis, Wilson's
        Drugs: steroids, alcohol
      - Clinical presentation
        Fatigue
        Anorexia
        Weight loss
        Abdominal pain
        Jaundice
        Ascites
      - Management
        Surgery (resection)
        Chemo (sorafenib)
        Liver transplant
      - Diagnosis
        CT/MRI staging
        Biopsy
      - Prevention
        Needle safety, safe sex, blood screening
        USS and a-FP screening (6m)
    - - Clinical presentation
        Fever
        Malaise
        Weight loss
        Abdominal pain
        Ascites
        Jaundice
      - Diagnosis
        Bloods (elevated ALP, bilirubin)
        MRI/CT
        ERCP
      - Aetiology
        Infection: worms (flukes), HBV, HCV
        Autoimmine: PSC
        Metabolic: DM
        Idiopathic: cysts
        Iatrogenic: biliary drainage surgery
        Drugs: N-nitroso toxins
      - Management
        Surgical excision, stenting
        Liver transplant
      - Epidemiology
        10% liver primaries
      - Prognosis<6m