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BETA LACTAM ANTIBIOTICS (PENICILLIN (CHEMICAL STABILITY (IN ALKALINE…
BETA LACTAM
ANTIBIOTICS
PENICILLIN
SOURCES
MOA
GENERAL STRUCTURE
CHEMICAL STABILITY
IN ALKALINE SOLUTION / BETA-LACTAMASE
IN ACID SOLUTION
WITH METAL IONS
CLASSES
NARROW SPECTRUM
PENZYLPENICILLIN / PEN G
PENICILLIN V
METHICILLIN
NAFCILLIN
OXACILLIN
BROAD SPECTRUM
CLASS I
AMPICILLIN
AMOXICILLIN
BECAMPICILLIN
CLASS II
PIPERACILLIN
CARBENICILLIN
TICARCILLIN
SAR
ALLERGIC REACTION
BETA-LACTAMASE INHIBITOR
CLASS I
e.g
CLAVULANIC ACID
SULBACTAM
TAZOBACTAM
MOA
CLASS II / CARBAPENEM
e.g
THIENAMYCIN
IMIPENEM
MEROPENEM
MOA
SAR
CEPHALOSPORINS
MOA
PROPERTIES
CHEMICAL STABILITY
METABOLISM
SAR
CLASSES
1ST GENERATION
2ND GENERATION
3RD GENERATION
4TH GENERATION
5TH GENERATION