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The skin (Dermis (Skin appendages (Apocrine sewat gland (Merocrine or…

- - - - Synthesized by fibroblasts
      - Strength and elasticity
  - - - Merocrine or eccrine gland : exocytosis
      - Reabsorbs Na and Cl
      - Dermcidin
    - - Merocrine or eccrine gland : exocytosis
      - Located deep dermis to subcutaneous fat
      - Secreate pheromone into hair follicle
      - Corynebacterium straitum
    - - Holocrine gland : rupture remnant
      - Produce sebum
      - Contain antimicrobial against propionibacterium acnes
  - - - Langerhans cells
        
        BM progenitor cells
      - Dermal dendritic cells
        
        :warning: Absence of Langerin and Birbeck
        
        Common myeloid precursor
      - Dermal macrophages
    - - Inflammatory dendritic skin cells
        
        CD80 and CD86
      - Plasmacytoid dendritic cells
        
        Type I IFNs : TLR7/8 and TLR9
        
        BM progenitor cells
- - - - ชั้นขี้ไคล้
      - Cell lining
        
        Corneocytes (keratinocytes)
      - Lamellar bodies
        
        Phospholipids
        
        Ceramides
        
        Sterols
        
        Hydrolytic enzymes
        
        Prevent transepidermal water loss
      - Desmosome
      - Anti-microbal peptide
        
        Cationic peptides
        
        Human beta-defensins 1-4
        
        Cathelicidins
        
        Psoriasin
        
        RNase
        
        Dermcidin
      - Desquamation
        
        Shedding to corneocytes
        
        14 days
    - - Basophilic keratohyalin granules
        
        Keratin + filaggrin
        
        Loricin
      - Program cell death
        
        Except keratin + filaggrin
        
        Prepare to corneocyte
      - Keratinization
        
        Cornified cell formation
        
        Keratin + filaggrin
        
        Hygroscopic
        
        Absorb moisture from air
        
        Loricin
        
        Transglutaminase-1
        
        14 days
    - - Cell lining
        
        Langerhans cell
        
        Birbeck granules
        
        Tenis backet
        
        Unknow function
        
        Langerin (CD207)
        
        Mannose involve immune
        
        Ag presenting cells
      - Spine-like, polyhedral
      - Lamellar granules
        
        Deliver lipids to intercellular space
      - Desmosome
        
        Cell to cell adhesion
    - - Cell lining
        
        Epidermal stem cells
        
        Melanocyte
        
        Neural crest derived
        
        Melanin synthesizing dendritic cells
        
        Transfer melanin ให้ keratinocytes
        
        Other location
        
        Middle layer of the eye (the uvea)
        
        Inner ear
        
        Vaginal epithelium
        
        Meninges
        
        Bone
        
        Heart
        
        Trigger
        
        UVA
        
        Rappid tanning
        
        Cause ROS
        
        Redistribution of melanosome
        
        UVB
        
        Delayed tanning
        
        Increase melanin production
        
        Albinism
        
        Defect of tyrosine hydroxylase or tyrosinase
        
        Autosomal reccessive
        
        Eye problems
        
        Hypopigment
        
        Merkel cell
        
        Tactile touch
      - Dermo-epidermal juction
        
        Hemidesmosome
        
        Basement mem. zone
        
        Anchoring fibrils
        
        Disturbance
        
        Blister
        
        Bullous pemphigoid
        
        Epidermolysis bullosa