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MM5 - Replication (iii) (Types of Repair (1) Mismatich Repair (MMR)…

- - - - hereditary non polyposis cancer (HNPC)
        
        = cancer syndrome from mutations (70%) in MLH 1+2 genes (makes mutated MutL)
  - - - 1) Cockayne syndrome
        
        premature ageing, photosensitivity, development delays, short lifespan, microcephaly
      - 2) Xeroderma Pigmentosum (XP)
        
        rare recessive skin disease
        
        lack of enzymes that repair thymine dimers
        
        extreme photosensitivity, skin cancer
        
        life expectancy = 29
- - - - hold broken strands, leaving ends accessible to nucleases, polymerases, ligases