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MM5 - Replication (ii) (DNA damage (UV light (fuses adjacent pyrimidines:…

- - - - RNAse 1
        
        removes all RNA except 5' nucleotide adjacent to DNA
        
        recognises DNA/RNA combo
      - Flap endonuclease 1 (Fen1)
        
        removes 5' nucelotide
        
        Also proofreads for DNAP alpha
- - - - ribonucleoprotein (RNA+protein)
      - increased telomerase activity: cancer (diagnostic tool + potential targeted therapy)
    - - 5-10 bps knocked off each time, normal ageing
        
        telomerase function declines
        
        if telomeres gone: apoptosis or permanent G0