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MM5 - Replication (i) (intro (in eukaryotees, complex, involves many…
MM5 - Replication (i)
intro
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complex, involves many proteins (@ least 13 DNAPs)
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for medicine: target for antibiotics, cancer therapies
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nucleosomes disassemble, old histones randomly distributed, new histones delivered, daughter strands reassemble
Requirements
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4) primer
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needed by DNAP (can only extend chain, not start from scratch)
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initiation
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from origin 2 replication forks move out in opposite directions (BUT can only read 3'-5', so how is this possible? SEMIDISCONTINUOUS REPLICATION)
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Step 2) replication
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DNAP
reads parent strand 3'-5', makes new strand 5'-3'
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