Legend #3: All patients who utilize the “Sacred Trinity” of an opioid, benzodiazepine, and muscle relaxant are either offering their medications or will in no time overdose. Hogwash! The first “Sacred Trinity” was a concurrent ingestion of a mix of the short-acting medications hydrocodone (Norco), alprazolam (Xanax), and carisoprodol (Soma). An alternate, long-acting medication from both of these 3 classes (opioid, benzodiazepine, muscle-relaxant) uniquely brings down the hazard. So does taking the medications independently.