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Term 1: Drug Overview (Antihistamines (1st Gen (Triprolidine,…

- - - - Cimetidine
      - Ranitidine
      - Nazitidine
      - Famotidine
    - - Omeprazole
      - Lansoprazole
      - Pantoprazole
      - Rabeprazole
      - Esomeprazole
    - - MgOH2
      - CaCO3
      - NaHCO3
- - - - Atropine (M)
      - Benzatropine (M)
      - Scopolamine (M)
      - Ipratropium (M)
      - Oxybutynin (M)
      - Nicotine (Low Dose) (Nm)
        
        Mech: Non-depolarizing block
      - Pancuronium (Nm)
        
        Uses: Paralysis surgery
        
        Mech: Competitive antagonist
        
        Mech: Non-depolarizing block
    - - Nicotine (High Dose) (Nm)
        
        Mech: Cause depolarizing block
        
        Is a Nm AGONIST
      - Succinylcholine (Nm)
        
        Uses Paralysis surgery
        
        Mech: Cause depolarizing block
        
        Is a Nm AGONIST
      - Botulinum Toxin (Nm)
        
        Mech: Prevent exocytosis of ACh
  - - - Carbachol (N/M)
      - Bethanechol (M)
      - Methanechol (M/N)
      - Acetylcholine (M/M)
      - Pilocarpine (M)
      - Nicotine (N)
    - - Echotiphate
      - Edrophonium (Diagnose)
      - Neostygmine (No BBB)
      - Physiostigmine (Cross BBB)
      - Donepezil (Cross BBB)
      - Pyridostigmine
      - Sarine Gas
      - Insecticide
- - - - Phenylehprine
      - Salbutamol
      - Mirabegron
      - Oxymetazoline
      - Isoprenaline
      - Dopamine
      - Noradrenaline
      - Adrenaline
      - Tebutaline
      - Brimonidine
      - Dobutamine
    - - MOA-A/B Inhibitor (eg. moclobemide)
      - Noradrenaline reuptake blockers (eg.TCA)
      - Displacement of Endogenous NA (pseudoephidrine, ephedrine)
  - - - Prazosin (a1)
      - Atenolol (b1)
      - Betaxolol (b1)
      - Propranolol (b1/2)
      - Sotalol (b1/2)
      - Timolol (b1/2)
    - - Reduce NA/A production
        
        Methyldopa
        
        Inhibit tyrosine hydroxylase
        
        False transmitter methyloradrenaline
        
        Uses: Hypertension
        
        Haemolytic anaemia / Hepatotoxicity
      - Reduce NA release (-ve feedback a2)
        
        Dexmedetomidine
        
        Reduce visceral vasocontriction
        
        Causes dry mouth
        
        Uses: Sedation