Please enable JavaScript.

Coggle requires JavaScript to display documents.

CELL WALL INHIBITORS (TYPE (CARBAPENEMS, MONOBACTAMS, CEPHALOSPORINS, B…

- - - - PBP Penecillin binding protein
      - Inhibition transpeptidase
    - - autolysin
    - - ability to cross the bacterial peptidoglycan cell wall to reach the PBPs in the periplasmic space
        
        charge
        
        hydropholbicity
        
        gram+ microorganisms have cell walls that are easily
        traversed by penicillins
        
        Gram- microorganisms, has an outer lippopylycharide membrane-barrier to the water-soluble penicillins. howerver there are porin (water-filled channel)
        
        size
  - - - PCN V/G
        
        fermentations of the fungus
        
        Pen V (not use for vein)
        
        Pen G (not use by gastric)
    - - susceptible (inhibits) by B-lactamase (penicillinase) produce by the resistant bacteria (Strep.Pneumonia)
      - treatment in Gram (+) cocci, bacilli
      - Gram (-) cocci
        
        Gonorrhea
        
        siler nitrat drops in newborn
        
        Penicillinase-produce bacteria using ceftriaxone, azithromycin, sepctinomycin for backup
      - Spirochetes (syphilis) no report for resistance
  - - - Methicillin cause interstitial nephritis, not use in clinical but on laboratory to indentify strain of S.A
- - - - cell wall impermable to the drug
      - lack a peptidoglycan (Mycoplasma pneumoniae)
    - - Plasmid mediated-Blactamase