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Connective Tissue (C.T) (Types (CT Proper (Dense C.T (Irregular (Collagen…

- - - - Phagocytic, resident monocyte = macrophage, antigen-presenting
        
        Control inflammation response if neutrophils can't resolve it
        
        Two types: M1 activated before M2
    - - Fat storage & hormone production
        
        single vacuole ( white fat), multiple vacuole (brown fat)
    - - produces protein fibers & ground substance of ECM
        
        Main cell of C.T; Target cell for growth factor
        
        adult fibroblast in G0 phase
        
        Myofibroblast help w/ wound healing, produces dense irregular scar tissue, also found in smooth muscle cells
    - - Fried egg appearance, high affinity for Fc receptor to IgE
        
        Loaded w/ histamine & other inflammatory factors
        
        Too much activity can lead to anaphalyxis
    - - Differentiate to only lineage
        
        surrounds blood vessels
  - - - Staining : Mostly nucleus
        
        T-Cells ( expresses TCR, CD 2,3,5,7), Natural Killer (CD16, 56,94, not antigen specifice unlike T & B cell
        
        B cells (BCR, CD 9,19,20) -> Plasma cells, which has a lot of cytoplasm
    - - Neutrophils
        
        Stain: No granular tissue color around polymorphic one-nucleus cell
      - basophils
        
        Stain: Nuclei and granule super imposed, completely blue
      - Eosinophils
        
        Stain: Red granular tissue, around polymorphic one-nucleus cell
    - - Kidney bean shaped cell
- - - - Stroma of soft organ
        
        PAS or silver stain to detect it
        
        produced by fibroblasts, reticular cells
        & Schwann ( neurological) cells
    - - vocal cords, lungs, arteries
        ( stretching & bending)
        
        resorcin-fuchsin stain for detection
        
        produced by fibroblast, vascular smooth
        muscle cells
        -Sun and smoking denatures elastin
    - - key element of all C.T
        
        strong/resistant to normal shearing
        & tearing forces
        
        Type I (most abundant) ,
        Type IV (in epithelial basal laminae)
- - - - Irregular
        
        Collagen Fibers in diffrent directions
        
        Dermis, submucosa of intenstine
      - Regular
        
        Lots of Collagen fibers
        arranged in parallel directions
        
        Few fibroblasts & ground substance
        
        Poor Vasculature
        
        Strength (Tendon, ligament, aponeurosis)
    - - Thin sparse fiber & lots of ground
        substance ( areolar tissue)
        
        Layer found under epithelial
        lining of tissues
        
        Diffussion of gases & nutrients
        Fills the space b/w muscle and nerve fibers