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H6 BONE (Vascularized & innervated) (Bone Cells (Osteoprogenitor…
H6 BONE
(Vascularized & innervated)
Connective Tissue
Outer Layer
Periostium
Inner Layer
Endosteum
Types of Bone
Macroscopic Layers
Trabecular (spongy, cancellous)
=internal support
Compact (corticol) bone
=dense, external surfaces
Bone Cells
Osteoprogenitor cells
Osteoblasts
4. Bone ECM Formation
Organic portion of ECM = type I collagen fibers (osteoid)
Inorganic portion of ECM = hydroxyapatite crystals (Ca) bound by MPG; BALP
Osteocytes
(in lacunae)
Form gap junctions with self and osteoblasts
--> bone remodeling
Bone Marrow
Osteoclasts
5. Bone Resorption
Inorganic portion of bone dissolved by H+
Organic portion of bone degraded by lysosomal enzymes
Ossification
Intramembraneous
(High O2)
Osteoprogenitor cells
#
Osteoblasts
#
Endochondral
(Low O2)
Chondrogenic cells
Chondrocytes
(hyaline cartilage)
KNOW NORMAL FOR EACH TYPE