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CAPSULES: Soft Gelatin (Formulation (Viscosity, Plasticizers, Important…
CAPSULES: Soft Gelatin
Formulation
Viscosity
Plasticizers
Important specification of gelatin: Bloom/Gel strength
Plasticizer & Gelatin ratio
Gelatin
Water
Colorants
Opacifiers
Titanium dioxide
Chelating Agents: Iron
Preparation: Filling materials
Solution fills
Suspension fills
Oily mixtures
Polyethylene glycol
Oily liquids
Manufacture
Plate process
Rotary die process
Supplementing drying
Sizing
Tumble drying
Packaging & Storage of capsules
Reciprocating die
Accogel capsule machine/Stern machine
Droplet method
Evaluation
Finished product testing
Visual inspection
In-process testing
Stability tests
Shell integrity test
Determination of shelf life
Invariability test
Weight variation test
Content uniformity test
Moisture permeation test
Disintegration test
Dissolution test
Packaging & storage