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Enzyme Regulation (Metabolic (Role of rate-limiting step, Feedback…
Enzyme Regulation
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Conformational Changes
Covalent Modification
Other
Addition of groups such as acetyl, ADP-ribose, or lipid moieties
Protein Kinase A
- Serine/threonine protein kinase
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Phosphorylation
- Phosphate is bulky and negatively charged
- Conformation changes caused by alterations in bond interactions resulting from phosphate
Allosteric enzymes
- Cooperativity
- Bind more in R state
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