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Antiviral drug (Side effects (Headache, dizziness, inflammation of…
Antiviral drug
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Storage
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Keep room temperature of 25 degrees Celcius, away from light and moisture
Indications
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They are also used to treat chronic hepatitis B when other options are not possible. It is effective against both HIV-1 and HIV-2
Mechanism of action
Lamivudine is an analogue of cytidine, it can inhibit both types (1 and 2) of HIV reverse transcriptase and also the reverse transcriptase of hepatitis B virus.
It is phosphorylated to active metabolites that compete for incorporation into viral DNA, they inhibit the HIV reverse transcriptase enzyme competitively and act as a 3'-OH group in the incorporated nucleoside analogue prevents formation of the 5'to3' phosphodiester linkage essential for DNA chain elongation and therefore, the viral DNA growth is termited
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