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BIOFILMS :zipper_mouth_face: :film_frames: (IMPORTANCE IN NATURE (EXAMPLES…
BIOFILMS :zipper_mouth_face: :film_frames:
IMPORTANCE IN NATURE
EXAMPLES
associated with catheters, pacemarkers, aortic vavles
staphylococcus auerus
staphylococcus epidermidis
stretococcus sanguis
refer to the nature article found in lecture when you have access
bacteria is not the only one that form biofilms
OVERVIEW
microorganism live in community
advantage for survival
share nutrients
sheltered from harmful factors
HOST COLONIZATION
ANTIBIOTIC RESISTANCE
pseudomonas aeruginosa
produce polysaccharides
increase pathogenicity
antibiotic resistance
quorum sensing system contain
AHLs
cyclic ... (chose one)
diguanosine monophosphate (c-di-GMP)
guanosine tetraphosphate
guanosine pentaphosphate
function
flagella synthesis
late biofilm maturation
occur when motility is reactivated to allow cell dispersal under conditions of flow
exopolysaccharide production
CROSSTALK - COMPETITION
polymicrobial biofilms are common
Ex: dental plaque in oral cavity :tongue:
patients with cystic fibrosis
two competitive parasites
location: lungs
C. albicans
a fungus
secretes Farnesol
repress biofilm formation
block virulent factors' production of P. aeruginosa
general info
the agent of oral thrush - fungus infection in the mouth
nosocomial infectins in diabetic or immunocompromised patients
P. aeruginosa
attach to Candida's hyphal cells (tail)
secrete reactive oxygen species
phospholipase C
phenazines
secrete AHLs :arrow_right: blocks Candida's conversion into hyphae
EUKARYOTES
candida albicans - FUNGUS
most common fungal agents of nosocomial infection
diseases associated
diabetic
immunocompromised
vaginitis
diaper rash
produce pseudohyphae / hyphae :arrow_right: pathogenic + produce biofilms
S. cerevisiae - YEAST
(not really disease)
forms biofilms on
plastic surface
soft agar
also on the surface of the wine after fermentation
produce flavors of spanish sherry wine :wine_glass: & sardinian wines :champagne:
not polymorphic
BAKING AND BREWING
