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Chapter 24 Systemic Drug Delivery: the foundation of periodontal diseases.…

- - - - Delivered into the pocket byfibers, gels, chips, powder, ointments, acrylic strips, or collagen films.
- - - - Anticollagenase Feature: affects the host response by stopping the production and secretion of collagenase by cells in the body such as PMNs
      - Concentration in Gingival Crevicular Fluid: Exhibits higher substantivity than other antibiotics
      - Adverse Effects, Drug-Drug Interactions, and Drug-Food Interctions: esophageal ulcers, nausea, vomiting, and diarrhea. GI upset
        
        do not take with dairy products bc it binds to calcium, stopping absorption
        
        Estrogens(birth Control)
        
        other antibiotics
      - Doxycycline hyclate & Minocycline HCl
    - - Adverse Effects, Drug-Drug interactions, and Drug-Food interactions
        
        5%-10% people allergic
        
        GI upset, nausea, vomiting, and diarrhea
        
        don't take with other bacteriostatic antibiotics
  - - - treat NUG
    - - Second-Generation Drugs: Azalides: Azithromycin, concentrates on phagocytes such as PMNs and macrophages and the inflammatory response
      - Adverse Effects, Drug-Drug Interactions, and Drug-Food Interactions
        
        Do not take with Statins: lovastatin and simvastatin
        
        antiasthma drug
    - - pseudomembranous colitis: allows clostridium difficile to grow in GI tract causing diarrhea and fever
    - - dizziness, convulsions, headaches, hallucinations, and joint and cartilage damage
      - Do not give to pts younger than 18 because it can stop cell growth
  - - - Bacterial invasion of spirochetes in NUG evade mechanical removal with instruments
    - - reevaluate with micro testing 1-3 months after tx
      - Proper selection and dosing
      - Bacteriostatic (suppress) or Bactericidal (kills)