Local Delivery: Controlled (sustained)-Release Drug Delivery: site specific, allow the therapeutic levels of the drug to be maintained in the perio pocket for longer period of time. Released within 24 hours after tx called sustained-release device. Past 24 hours called controlled-release. placed inside pocket. active ingredient released from material, works over several days, then material is absorbed. once absorbed healing can begin. doesn't enter blood stream so no adverse effects, ACTISITE, PERIOCHIP, ATRIDOX, ARESTIN
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