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Muscle signal transduction (Diff fr nerve-nerve synapse (no spatial…
Muscle signal transduction
Action potential
axon terminal of presynaptic neuron
Voltage-gated Ca+ channels
Acetylcholine-containing vesicles crossing motor end plate
Ligand-gated Na+ channel at subneural clefts of muscle
Na+ into muscle cell
End plate potential
smaller than -80-(-90) mV = threshold
muscle = excitable but no contration
larger than threshold
action potential starts
1 more item...
Acetylcholinesterase = releases + reabsorbed to neuron after use
Acetylcholine = broken down
Muscle composition
long muscle cells, fibers
multiple myofibrils
actin + myosin filaments
1 nerve ending only
1 myofibril
myosin
biggest protein 250kDA
2 heavy chains w/ 2 globular proteins
A band
Actin
small protein 42kDA
I band
Z disk at either end
distance = sacromere 2um
Tropomyosin
Troponin
outer membrane = sarcolemma
continuous w/ sarcoplasmic reticulum
Depolarizes
T-tubules help attach to other
branch out
touch every myofibril at multiple pts
connected to extracullular fluid
same memb potential
capacity for excitation
excitation-contraction coupling
Diff fr nerve-nerve synapse
no spatial summation of signals
#
muscle potental = longer (5x)