CHEMOTHERAPY: uses anti-cancer drugs that may be given intravenously, orally, topically,.drugs taken by mouth or injected into a vein are called systemic chemotherapy, they enter the bloodstream to reach through the body, making this treatment useful for vaginal cancer that has spread to other part of the body, chemo drugs include cisplatin, carboplatin, paclitaxel, fluorouracil, dicitaxel, irinitecan