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Complex I (Inactive (Block O2.- at a key site, Conditions seem to be met,…
Complex I
Inactive
Block O2.- at a key site
Conditions seem to be met
Curtail ATP synthesis
NO antagonism
Remains inactive
Protect against RET
Constrains O2.-
Could explain rotenone data
Proportional
Drive mROS at the matrix dehydrogenases?
Attractive
Essential complex
Is it the full complex
Minute time-scale
Mito-nuclear match
Active fertilisation
Explains the ROS
Hard to reconcile with rotenone?
Low concentration
Given too late
Off-target effect
Contributes to pmf
Essential to avoid mitophagy