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salicylic acid(skin) (mechanism of action (Salicylic acid directly and…
salicylic acid(skin)
mechanism of action
Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid.
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Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG.
It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to the phenolic acceptor.
Nursing concideraction
Contraindication
Diabetes mellitus, peripheral vascular disease
Topical salicylic acid preparations in concentrations greater than 6% are contraindicated in patients with diabetes mellitus
Influenza, varicella
The potential for Reye's syndrome should be considered with administration of salicylic acid products in children and adolescence
Accidental exposure, ocular exposure
Avoid accidental exposure of salicylic acid products to the eyes.
Salicylate hypersensitivity
Salicylic acid preparations are contraindicated in patients who have previously exhibited salicylate hypersensitivity
Storage conditions
Store Aspirin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C
Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container.
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Route of Administaration
Following topical application, percutaneous absorption of salicylic acid does occur; however, systemic exposure is considered negligible with normal prescription use.
Roughly 10% of applied salicylates can remain in the skin after dermal application; however, acute toxicity via dermal exposure is rarely seen for salicylic acid.
Salicylism has occurred using high concentrations of salicylic acid on widespread areas of hyperkeratotic skind.
, but cases resulting from topically applied salicylic acid cosmetic or acne products have not been reported
Side effects
black, bloody, or tarry stools
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severe nausea, vomiting, or stomach pain
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swelling, or pain lasting longer than 10 days
Indications
Aspirin is used to treat mild to moderate pain, and also to reduce fever or inflammation.
It is sometimes used to treat or prevent heart attacks, strokes, and angina. Aspirin should be used for cardiovascular conditions only under the supervision of a doctor.
Adults, Adolescents, and Children 2 years and older
Apply to the affected area twice daily and rub in until completely absorbed.
defination
Salicylic acid is a keratolytic (peeling agent). Salicylic acid causes shedding of the outer layer of skin.
Salicylic acid is a keratolytic (peeling agent). Salicylic acid causes shedding of the outer layer of skin.