HIV clinical staging

adults and adolescents clinical staging

children clinical staging

clinical stage 2

stage 1

Moderate unexplained weight loss (<10% of presumed or measured body weight)

Recurrent respiratory tract infections (sinusitis, tonsillitis, otitis media, pharyngitis)

Herpes zoster

Angular cheilitis

Recurrent oral ulceration

Papular pruritic eruption

Fungal nail infections

Seborrhoeic dermatitis

asymptomatic, persistent generalized lymphadenopathy

clinical stage 3

clinical stage 4

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Unexplained severe weight loss (>10% of presumed or measured body weight)

Unexplained chronic diarrhoea for longer than 1 month

Unexplained persistent fever (intermittent or constant for longer than 1 month)

Persistent oral candidiasis

Oral hairy leukoplakia

Pulmonary tuberculosis

Severe bacterial infections (such as pneumonia, empyema, pyomyositis, bone or joint infection, meningitis, bacteraemia)

Acute necrotizing ulcerative stomatitis, gingivitis or periodontitis

Unexplained anaemia (<8 g/dl), neutropaenia (<0.5 × 109/L) and/or chronic thrombocytopaenia (<50 × 109/L)

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HIV wasting syndrome

Pneumocystis (jirovecii) pneumonia

Recurrent severe bacterial pneumonia

Chronic herpes simplex infection (orolabial, genital or anorectal of more than one month in duration or visceral at any site)

Oesophageal candidiasis (or candidiasis of trachea, bronchi or lungs)

Extrapulmonary tuberculosis

Kaposi sarcoma

Cytomegalovirus infection (retinitis or infection of other organs)

Central nervous system toxoplasmosis

HIV encephalopathy

Extrapulmonary cryptococcosis, including meningitis

Disseminated nontuberculous mycobacterial infection

Progressive multifocal leukoencephalopathy

Chronic cryptosporidiosis

Chronic isosporiasis

Disseminated mycosis (extrapulmonary histoplasmosis, coccidioidomycosis)

Lymphoma (cerebral or B-cell non-Hodgkin)

Symptomatic HIV-associated nephropathy or cardiomyopathy

Recurrent septicaemia (including nontyphoidal Salmonella)

Invasive cervical carcinoma

Atypical disseminated leishmaniasis

clinical stage 1

clinical stage 2

Asymptomatic
Persistent generalized lymphadenopathy

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Unexplained persistent hepatosplenomegaly

Recurrent or chronic upper respiratory tract infections (otitis media, otorrhoea, sinusitis, tonsillitis)

Herpes zoster

Lineal gingival erythema

Recurrent oral ulceration

Papular pruritic eruption

Fungal nail infections

Extensive wart virus infection

Extensive molluscum contagiosum

Unexplained persistent parotid enlargement

clinical stage 3

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Unexplained moderate malnutritionb not adequately responding to standard therapy

Unexplained persistent diarrhoea (14 days or more)

Unexplained persistent fever (above 37.5°C, intermittent or constant, for longer than one 1 month)

Persistent oral candidiasis (after first six weeks of life)

Oral hairy leukoplakia

Lymph node tuberculosis; pulmonary tuberculosis

Severe recurrent bacterial pneumonia

Acute necrotizing ulcerative gingivitis or periodontitis

Unexplained anaemia (<8 g/dL), neutropaenia (<0.5 × 109/L) or chronic thrombocytopaenia (<50 × 109/L)

clinical stage 4

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Unexplained severe wasting, stunting or severe malnutritiond not responding to standard therapy

Pneumocystis (jirovecii) pneumonia

Recurrent severe bacterial infections (such as empyema, pyomyositis, bone or joint infection, meningitis, but excluding pneumonia)

Chronic herpes simplex infection (orolabial or cutaneous of more than 1 month's duration or visceral at any site)

Oesophageal candidiasis (or candidiasis of trachea, bronchi or lungs)

Extrapulmonary tuberculosis

Kaposi sarcoma

Cytomegalovirus infection (retinitis or infection of other organs with onset at age older than one month)

Central nervous system toxoplasmosis (after the neonatal period)

HIV encephalopathy

Extrapulmonary cryptococcosis, including meningitis

Disseminated nontuberculous mycobacterial infection

Progressive multifocal leukoencephalopathy

Chronic cryptosporidiosis (with diarrhoea)

Chronic isosporiasis

Disseminated endemic mycosis (extrapulmonary histoplasmosis, coccidioidomycosis, penicilliosis)

Cerebral or B-cell non-Hodgkin lymphoma HIV-associated nephropathy or cardiomyopathy