HIV-associated Kaposi sarcoma causes dark blue lesions which can occur in a variety of locations including the skin, mucous membranes, gastrointestinal tract, lungs or lymph nodes. The lesions usually appear early in the course of HIV infection. Treatment depends on the lesions’ symptoms and location. For local lesions, injection therapy withvinblastine has been used with some success. Radiotherapy can also be used, especially in hardto-reach sites such as the inner mouth, eyes, face and soles of the feet. For severe widespread disease, systemic chemotherapy is the preferred treatment. Most drugs for the chemotherapy of Kaposi sarcoma are included in the WHO essential drugs list. However, since international generic drug suppliers appear to offer only vincristine and methotrexate, the availability of drugs to treat the disease is limited in developing countries.