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Ovarian Cycle (hypothalamus releases GnRH (GnRH acts on gonadotrophs in…
Ovarian Cycle
hypothalamus releases GnRH
GnRH acts on gonadotrophs in anterior pituitary
Anterior pituitary
Follicular Phase
anterior pituitary releases FSH and LH; FSH is higher than LH
FSH acts on granulosa cells
stimulates synthesis of estrogen and estradiol
high levels of estrogen toward end of follicular phase
positive feedback loop (increases estrogen)
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low levels of estradiol at beginning of follicular phase
negative feedback (increases estrogen)
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LH acts on theca cells and granulosa cells
Luteal Phase
negative feedback decreases all levels: LH, FSH, estradiol and progestrone
Ovulatory Phase
extreme increase in estradiol causes the anterior pituitary releases more LH than FSH
decrease in FSH causes a decrease in estradiol
negative feedback to decrease estradiol
progesterone increases due to increase LH
positive feedback to increase progesterone