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Assisted Robotic Microscopy (Assisted pathology service (Use cases) (Mohs…
Assisted Robotic Microscopy
Adapters
Stage
Piezoelectric
Using different frequencies to move back and forth
Using piezo discs to cause rotation of a wheel (How to describe?)
The stage is one massive piezo disk, and the specimen moves according to vibrations
2 stage Z control - Micro Z control where DC current passing thru piezo can achieve Z control, and a larger kinetic or large Z control can have faster and larger adjustments
https://youtu.be/L0Rkfqp2fIA
Electromagnetic
electromagnetic attraction and repulsion, depending on polarity of magnetic force
? Magnetic levitation or sample?
Mechanical
Step motors
Rubber band and pulley
Does the sample always have to be in the horizontal place?
What if we changed the sample to vertical plane, would that make control easier?
Automated control with learned patterns
Magnefication (Object Lens)
Mechanical control of existing magnification sys
Optic add-ons
Combine with additional focus optics
Can camera be high def enough to compensate?
Focus
Optic
Standalone lens
add-on lens that can adjust focusing length, in between image capture source and optical pathway
Lens that can change magnification on the eyepiece (Multiple lenses of varying magnification)
Mechanical
Camera mount
Feedback loop between camera and stage
Camera focusing using camera optics
Illumination
Standalone light source
Use a flat LED
Use various light sources instead of single source
Mechanical adapter
Control
Client Interface (software)
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Aperio patents - Capture different focal planes or Z stack data (focal pints, heights, vector data)
Use 2 cameras or more to speed up process (Light's camera) With reconstruction (new imaging)
Camera which looks at top AND bottom (will this actually work?)
Can Digital Telepathology actually incorporate slicing of target organ and loading of slide? Like a CT scan, but with real tissue. Auto-histopathology
Can it be other wavelengths?
Client hardware
Smart phone
Touch screen
Adapter simulating microscope controls
Shared drive /template for editing pictures (Like coggle for slides)
Can we put a scanner in a smart phone actually? like a smart phone taht can transform into a digiatl pathology scanner
Tablet
Touch screen
Pen for control
Visual reality/ Augmented reality
Voice recognition
Gesture recognition
Smart gloves(Minority report control)
VR virtual lab with VR headset
Xbox kinect for pathology (Microsofft has it?)
AR onto microscope slide (Google)
Real time VR/3D!!
Laptop
Keyboard & Mouse
Joystick haha
Auto-microtome
Control of microtome and specimen slicing based on 3D model
Reconstruction of 3d slices after microtome, and digital slide
Image Process
Image Recognition
Database with DNN
Google - highlighting areas with cancer cells
Orchestration control and image
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Slide Processing
Is the best way to process a slide a mosaic?
Video capture instead of picture
scan the slide like a photocopy machine
Assisted pathology service (Use cases)
Mohs Surgery
Nonlinear miscroscopy
Enspectra
OCT
Photoacoustic
Can we do a control system for automated Mohs?
Robotic surgery
Automated decision making and live scanning. Can do a quick digital scan to make sure adequate margins in 1 sample, before excision!
Tumor margin detection during operation
fat contents for transplant
Fatty liver biopsy on the spot
Service to automatically take a core of liver and scan it in real time, like a gun that can take a biopsy, while also preparing the specimen and acting as a microscope
cardiovascular?
rural areas
Telepathology service at low cost
Automated telepathology service
Automated biopsy service
cytology
second opinion
3D image collection