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Inhalational injury (Pathophysiology (Systemic toxicity (Carbon monoxide…

- - - - CO is a product of combustion (COHb levels: >10% headache, >20% confusion, >40% convulsion/coma, >60% death)
      - Colourless, odourless, tasteless
      - Pathophysiology: Binds Hb (250 x affinity 02), shifts 02 dissociation curve left (resulting in reduced tissue 02 delivery), Inhibits CYP oxidase in mitochondria resulting in reduced 02 use in cells
      - Treatment: 100% 02 to all burns victims (reduces CO t1/2 from 4hrs to 40mins), HB02 increases elimination but no effect on long term outcome and limited availability and access
    - - CN is a product of burning plastics
      - Inhibits CYP oxidase in mitochondria (reduced 02 use by cells - anaearobic resp increases resulting in lactic acidosis)
      - Measurement of blood CN can be made but not immediately available