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L3 CELL SIGNALLING I (cell life (grow + divide, differentiate, survive,…
L3 CELL SIGNALLING I
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signal transduction
receptor protein, activating
intracellular signal molecules, which alters
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target proteins, which creates
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OUTCOMES
- Understand that cell survival depends on a complex communication network
- Be able to define the terms "hormones" and "receptors”
- Be able to classify hormones by - site of synthesis and action (the "physiological way") - chemical properties (the "biochemical way")
- Be able to define 7 steps essential for efficient and specific information transfer
hormones
chemical messages that coordinate activities of different cells in organism; diverse group of chemical types
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receptor
membrane-bound or soluble protein/protein complex which exerts a physiological effect after binding its natural ligand
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- hormone binding domain (essential): specifies which hormone binds
- signal transduction domain (essential): exact biochemistry of this region varies with receptor type
- transmembrane domain (in most but not all)
