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case 5 (ELISA (antigen absorbed onto plastic plate, free antigen washed…

- - - - reduced ability to mount a delayed type hypersensitivity reaction
      - loss of ability to generate an antibody response
  - - - infected CD4 cells present viral peptides on MHC class 1
        
        antibody and complement
        
        anti-gp120 binds to CD4 resulting in complement fixation and cell lysis
        
        antibody-dependent cell mediated cytotoxicity
        
        Macrophages and NK cells bind to the FC portion of the anti-gp120 antibody
        
        CD8 cytotoxic T cells
        
        kill virally infected cells expressing the HIV antigenic peptides with their class 1 MHC
- - - - make up mesh around cortex
      - structural
      - secrete factors for T cell development
    - - surround developing thymocytes
      - express class 1 and 2 MHC
    - - provide structure for the medulla
      - play an important part in T cell tolerance
- - - - weight loss
      - night sweats
      - fever
      - diarrhoea
- - - - inhibit synthesis of petidoglycans of the cell wall
      - activate cell wall destructive enzymes
    - - effect permeability of phospoholipid membrane
    - - inhibit protein synthesis by altering ribosomal function
    - - block metabolic pathways essential for life
    - - interfere with replication of DNA/RNA
- - - - gp41
        
        binds to cell chemokine causing receptor fusion and allowing the viral nucleocapsid to enter the cell
      - gp120
        
        involved in binding to the CD4 of the host cell
    - - CD4 T cells
      - monocytes
      - dendritic cells
  - - - copies viral RNA into double stranded DNA
      - virus can lie dormant in this stage
        
        latent stage
    - - viral RNA is transcribed from proviral DNA using host cell's protein synthesis
      - viral proteins and RNA assemble into particles that bud from the host cell
      - budding virus uses some of the host cell's cell membrane to form the viral envelope
      - new viral capsules now invade other cells
- - - - terminates DNA chain elongation
    - - inhibits enzymatic activity
    - - inhibits viral cleavage
    - - toxicity
        
        bone marrow
        
        gut
      - complicated regiment that is intrusive to lifestyle
      - expensive