Please enable JavaScript.
Coggle requires JavaScript to display documents.
MM19 - Genetics of Common, Complex Disease (i) (Genome Wide Association…
MM19 - Genetics of Common, Complex Disease (i)
rare disease
-
usually monogenic (single locus), mendelian, felly penetrant, chronic, severe/life-threatening, early onset, biologically simple
-
e.g. neurofibromatosis, huntington's, PKU, sickle-cell anaemia
common disease
polygenic (several loci, reduced penetrance)/multifactorial (genetic+environmental, e.g. MS), biologically complex
-
usually later onset, severity varies
-
e.g. cancer, obesity, hypertension, diabetes
-
-
Schizophrenia
chronic, severe, disabling brain disorder
-
-
-
-
GWAS
-
-
-
indicated that factors contributing to the disease are: immune disregulation, Ca2+ signalling, glutamatergic neurotransmission