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Theme Two (Drugs in society (Poisons standard
Federal govt.
Schedules …
Theme Two
Drugs in society
Generic substitution
- Pharmacist can suggest generic brand
Australian register for therapeutic goods (ARTG)
- listed (low risk)
- registered (high risk)
- both cannot make therapeutic claims to the public
Poisons standard
- Federal govt.
- Schedules
- Labelling and storage
Schedules
- no schedule = supermarket
- S1 = nothing
- S2 = pharmacy
- S3 = pharmacist only
- S4 = prescription
- S8 = controlled drug
Determinants
- Risk
- Level of control required
-
Marketing
- S2 = widely marketed
- S3 = Only appendix H products
Regulation
- Self regulation
- Drug promotion to doctors - biased
- Drug promotion to patients - long time frame
Selective toxicity
- Drug is going to poison cells affecting the body
- But only the bad cells
- Shit thats exclusive to the pathogen
e.g. peptidogylcan (amoxyllin is penicillin)
Viruses
- replicate intracellularly
- targets specific viral proteins
- Pathogenic (malaria)
- Commensal
- Pathogenic sometimes (HIV virus)
Superinfection
- balance between pathogenic and non-pathogenic is fked
- Thrush when too much antibacterial drugs
Resistance
- Natural selection
- Not using the drug properly
Asthma
Relievers
- short acting beta-agonists
- Subutamol
-
Symptom controllers
- long acting beta-agonists
Preventers
- stop leukotrines (bronchoconstrictors)
- steroids
- leukotriene antagonists
- Thrombotic Stroke
- Embolic stroke
- Haemorrhaging stroke
Hypertension
- beta-blocker
- alpha-blocker
ACE inhibitor
- Stops angiotensin 1 to angiotensin 2
- lowers BP
Angiotensin receptor antagonists
Cholesterol
- Statins inhibits enzyme in the liver (HMG)
- stops the synthesis
- LDL = bad receptor
- increase reception of LDL receptor so uptake is better
Drugs for sex
The pill
- Classic: fixed dose of hormones
- Phasic: 2-3 diff doses depending on the phase
-
ED
Causes
- Organic: disease, smoking
- Psychogenic: depression etc
Vasodilators (corpus cavernosum = erection)
- papaverine
- Alprostadil
- Viagra = PDE-5 = Cyclic-GMP not broken down = longer
- in response to NO (sexual stimulation)
-
Naming of drugs
- Chemical names
- Generic name
- Trade name