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Lead Exposure Path Exam 5 (PATHOGENESIS (Compete for Ca ions Bone issues…
Lead Exposure Path Exam 5
Urban Air
Water (plumbing
House Dust (paint contamination)
Lead-Glazed Ceramics
Food (lead solder in cans)
Imported from Mexico (candy wrappers)
Target Shooting
Lead Soldiers
Stored:
bone
teeth
1/2 life = 30 years
PATHOGENESIS
Compete for Ca ions
Bone issues
Nerve transmission deficits
Brain development deficits
Interfers w/ normal epiphyseal plate remodeling
Inhibits healing of fractures
Hemolysis of RBCs
Inhibits membrane-assoc. enzymes
Renal damage
Uric acid retention
Impaired Vit D Metabolism
Inhibits 2 Enzymes in Heme Synthesis
:red_cross:
Ferrochelatase
:red_cross:
Gamma-Aminolevulinic Acid Dehydratase
Microcytic, Hypochromic Sideroblastic Anemia
Course, Basophilic Stippling = small aggregates of RNA
Tests:
CBC not diagnostic
Long-bone radiograph :arrow_right: lead-containing foreign body
:arrow_up:
Aminolevulinic Acid (urine)
:arrow_up:
Protoproporphyrin (blood)
SOURCES OF LEAD POISONING