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Kinetics (Movement of drug molecules (How fast a dosage form will…
Kinetics
Movement of drug molecules
How fast a dosage form will disintegrate and dissolve
What the target tissues will be
How long will it take to get to the target tissues
How long will it stay at the target tissues
How and when will the drug be excreted
Key steps
Disintegration / dissolution
Absorption
Stay in gut
Active transport
Passive diffusion
Distribution
Tissue specificity
pH
Blood flow
Excretion
pH of urine
Low pH
Drug more likely to be reabsorbed
High pH
Drug will be excreted
Active transport
Penicillin
Feces
High pH in lower bowel
Causes drug ionization
Rate of transport
Lipophilicity
Affinity for protein molecules
Albumin
Tendency to ionize
Path through the body
Oral tablet
Stomach
Duodenum
Capillaries
Portal vein
Liver
Heart
Lungs
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Bile duct
Gall bladder
Injection