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Pharmacology of Neurodegenerative Disorders (Parkinson's (Levodopa…
Pharmacology of Neurodegenerative Disorders
Alzheimer's
Acetylcholinesterase inhibitors
donepezil
rivastigmine
galantamine
Abeta targeting antibodies
NMDA Receptor Antagonists / Partial Antagonists
Memantine
g-Secretase inhibitors
Parkinson's
Levodopa-carbidopa
Most effective, good choice for elderly
Dopamine agonist
Not as effective as Levodopa, not tolerated by elderly
Anticholinergic
For tremor in younger patients
Amantadine
Mild to modest effect in younger patients
Monoamine oxidase type B (MAO-B) inhibitor
Catechol-O-methyl transferase (COMT) inhibitor
Epilepsy
Na+ channel inhibition
Carbamazepine
Lamotrigine
Phenytoin
Ca2+ channel inhibition
Valporic acid
Ethosuximide
GABAA receptor modulators
Benzadiazepines
Barbiturates
Thiopental
Pentobarbital
Inhibitors of GABA metabolism
Rasageline
Siligeline
GABA analogues
Gabapentin
Pregabalin
Targeting of glutamate
Felbamate
Rufinamide
