Please enable JavaScript.
Coggle requires JavaScript to display documents.
Benznidazole (MECHANISM OF ACTION (Generate radical species which can…
Benznidazole
MECHANISM OF ACTION
-
The nitro group of nitroimidazoles is believed to be reduced by the pyruvate:ferredoxin oxidoreductase complex to create a reactive nitro radical species.
Inhibits DNA, RNA, and protein synthesis within the T cruzi parasite
DNA in parasites affected by benznidazole has been found to undergo extensive unpacking with overexpression of DNA repair proteins supporting the idea of DNA damage contributing to the mechanism of the drug
-
ADME
-
-
-
ABSORPTION
-
Peak plasma time: 2 hr (fasting); 3.2 hr (high-fat, high-caloric meal)
-
-
-
ORIGIN
-
Granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017
INDICATION
Treatment of Chagas disease (American trypanosomiasis) caused by Trypanosoma cruzi.
This indication is approved under accelerated approval based on the number of treated patients who became Immunoglobulin G (IgG) antibody negative against the recombinant antigens of T. cruzi
Dose
Dosage based on body weight; 100-mg tablets are scored and can be split in half (50 mg) or quarters (25 mg) to enable precise dosing
-
-
-
-
-
-
-
-
-
